Giant cell tumor of bone (GCTB)
Giant cell tumor of bone is a rare, benign tumor. It usually develops near a joint at the end of the bone. The tumor is histologically characterized by multinucleated giant cells with a background of mononuclear stromal cells. The multinucleated giant cells appear similar to osteoclasts, which led to the older term osteoclastoma. Despite being categorized as a benign lesion, GCT may be locally aggressive and recur after surgical resection.