Amyloidosis

Amyloidosis is a disorder of protein folding in which normally soluble proteins are deposited as an insoluble proteinacous material in the extracellular matrix of tissue. At least 27 precursor proteins can form amyloid. The deposits may be localized to one organ or may be systemic. Amyloid deposition may be subclinical or may produce a diverse aray of clinical manifestations.