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Serum Sickness

  • Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. The term "serum sickness" was introduced by von Pirquet and Schick, who published a book with that title (Die Serumkrankheit) in 1905.

  • Symptoms usually develop within 1-3 weeks after receiving the antiserum and are recognized by fever, swollen, joints, and a rash in most cases. A medical history, physical examination, and simple blood and urine tests are used to diagnose Serum Sickness

  • The standard treatment for Serum Sickness is with antihistamines and NSAIDs, which can help reduce symptoms

  • The prognosis is very good, and most individuals can expect a full recovery within a few weeks. While complications are generally uncommon, individuals may develop anaphylaxis, swelling of the face, and nerve inflammation.









McMaster Internal Medicine

Milton S. Hershey Medical Center

Serum Sickness Following Treatment with Rituximab (

Serum sickness associated with rituximab in a patient with hepatitis C virus-related mixed cryoglobulinaemia (