Back to A-Z

Childhood sarcoidosis

Children of both sexes develop sarcoidosis less commonly than adults. The clinical manifestations in older children are similar to those in adults. However, in children younger than 5 years the characteristic presentation includes mild constitutional symptoms; painless, boggy, and effusive large-joint polyarthritis and tenosynovitis; skin lesions; uveitis; and lymphadenopathy and splenomegaly without typical lung disease.This presentation must be differentiated from the rare autosomal dominant familial granulomatous disorder Blau syndrome, which is caused by a genetic mutation of the NOD2/CARD15 protein. Children with sarcoidosis usually have a spontaneous resolution of disease, but some experience residual complications. Corticosteroids with or without methotrexate are the treatment of choice for children with severely symptomatic or progressive disease.






Boston Children's Hospital

Previous Next