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Sickle cell dactylitis (Hand–foot syndrome)

Hand–foot syndrome, or sickle cell dactylitis, is a problem in infants with sickle cell disease. Children present with acute pain and swelling diffusely in the fingers or toes, usually as a first manifestation of sickle cell disease. Fever and leukocytosis may accompany the dactylitis. The etiology is thought to be local bone marrow ischemia. Subperiosteal new bone formation may be seen on radiographs of the metacarpal or metatarsal bones 2 weeks after the acute episode. Symptoms generally spontaneously subside in a few weeks.


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