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Giant cell tumor of bone (GCTB)

Giant cell tumor of bone is a rare, benign tumor. It usually develops near a joint at the end of the bone. The tumor is histologically characterized by multinucleated giant cells with a background of mononuclear stromal cells. The multinucleated giant cells appear similar to osteoclasts, which led to the older term osteoclastoma. Despite being categorized as a benign lesion, GCT may be locally aggressive and recur after surgical resection.


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