Hyperuricemia is defined as a serum uric acid concentration >7.0 mg/dL in males and >6.0 mg/dL in females. Body mass index and alcohol intake are the most important predictors of hyperuricemia and gout in the majority of individuals.
Acquired causes of hyperuricemia:
Urate overproduction: excess dietary purine consumption, accelerated hepatic ATP degradation in alcohol abuse or fructose ingestion, and increased nucleotide turnover in myeloproliferative and lymphoproliferative disorders
Urate underexcretion: renal disease, lead nephropathy (saturnine gout), inhibition of tubular urate secretion (keto- and lactic acidosis), and miscellaneous causes such as hyperparathyroidism, hypothyroidism, and respiratory acidosis
Drugs that cause hyperuricemia due to decreased renal excretion of urate (mnemonic CAN’T LEAP )
Lasix (furosemide) (and other loop diuretics)
Aspirin (low dose)
Other drugs that can cause hyperuricemia by unknown mechanisms include levodopa, theophylline, and didanosine.