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Chronic recurrent multifocal osteitis (CRMO)

Chronic recurrent multifocal osteitis is a chronic sterile inflammatory and multifocal disease of bone that preferentially affects children, females (F > M 2:1). Bone sites involved differ according to age of the patient. The metaphysis of the long bones is preferentially affected in children and adolescents, whereas anterior thoracic, vertebral, and/or unilateral sacroiliac lesions predominate in adults. Bone biopsies are necessary to rule out bacterial osteomyelitis, tumor, and eosinophilic granuloma. Many patients with CRMO have Crohn’s disease or psoriasis or skin lesions associated with (SAPHO) Over time, most patients with CRMO evolve to satisfy criteria for a spondyloarthropathy, although they usually are HLA-B27 negative. Treatments used have been similar to those used in SAPHO.


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