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ANA and ANCA antibodies

In the context of clinical manifestations, if analysed with high quality laboratory methods and correctly interpreted, ANA and ANCA are an essential tool in the differential diagnosis of rheumatic diseases.

Neither ANA nor ANCA, however, are pathognomonic markers of rheumatic diseases and they do not have a reliable negative predictive value.

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adapted from Praxis 2020; 109 (5): 325–331