Acromegaly is a rare syndrome that results when the
anterior pituitary gland produces excess growth hormone (GH) after
epiphyseal plate closure at puberty.
Arthropathy is seen in up to 74% of affected patients. The knees, shoulders, hips, lumbosacral spine, and cervical spine are the most frequently symptomatic areas, but the hands reveal the most characteristic radiographic changes (e.g. soft tissue thinkening, deformation of epiphyses with squaring of enlarged terminal phalanx/phalanges, chondrocalcinosis, increased joint/disc space etc.)